920 Complications of Facial Cosmetic Botulinum Toxin an Injections: A Systematic Review and Meta-Analysis

Abstract Aim Botulinum toxin A (BoNT-A) injections are a popular non-surgical procedure for facial rejuvenation with increasingly pervasive use in cosmetic clinical practice. This study analyzes the safety profile of glabellar and forehead BoNT-A assesses influence practitioner factor type on complication rate. Method systematic search MEDLINE EMBASE was performed studies reporting complications after or region. random effects meta-analysis carried out to assess Where there were sufficient Randomized-Controlled Trials (RCTs) network performed. Results Of 556 identified articles, 24 included final quantitative analysis 4,268 injection sessions 1,234 placebos. Frequently observed treatment-related intervention group headache, local skin reactions neuromuscular symptoms. Overall rate 16%. The odds ratio developing from Abobotulinum compared placebo 1.62 [1.15, 2.27; p>0.05]. Onabotulinum 1.34 [0.52, 3.48; In 30% injectors doctors, whilst remaining 70% training status practitioners not reported. Conclusions Cosmetic region appear be safe majority mild transient. Nevertheless, literature demonstrates heterogeneous lack consistency definition complications.